PREVENTION OF Treponema denticola CAUSING GUM DISEASE BY QUERCETIN OF GINGER
SUNANYA DAS
Centurion University of Technology and Management, Odisha, India.
MANASRANJAN KHATEI
Centurion University of Technology and Management, Odisha, India.
SANAM BISHOI
Centurion University of Technology and Management, Odisha, India.
MUKUNDJEE PANDEY *
Centurion University of Technology and Management, Odisha, India and Go to Market Laboratory, Gram Tarang, Odisha, India.
DIPANKAR BHATTACHARYAY
Centurion University of Technology and Management, Odisha, India and Go to Market Laboratory, Gram Tarang, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Gum disease is caused by Treponema denticola. Thmidylate Synthase is one of its major enzymes of that pathogen. Ginger extract is known to cure gum disease. The plant extract contains different phytochemical compounds. By using “Biovia Discovery Studio”, the molecular docking of the phytochemicals with the enzymes was studied. The results showed that Quercitin can deactivate the Thymidylate Synthase enzyme thereby interrupting the microbe’s life cycle.
Keywords: Phytochemical, ginger metabolic pathways, gum disease, Treponema denticola.
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References
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