Original Research Article

MAGNITUDE OF GENERALIZED ANXIETY AMONG HEALTH PROFESSIONALS WORKING ON COVID-19 AT DILLA REFERRAL HOSPITAL DILLA, ETHIOPIA

CHALACHEW KASSAW, YIGREM ALI

Asian Journal of Advances in Medical Science, Volume 2, Issue 3, Page 13-20

Background: In Ethiopia, Corona confirmed cases are increasing from time to time, and health care professionals were front line exposed risky groups for infection. The mental health of the health professional is vital for better care and treatment outcome patients. This study aimed to determine the health care professional’s current mental health status and associated factors in response to the pandemic.

Methods: A hospital-based cross-sectional survey using a consecutive sampling technique was employed from April 5-10, 2020. Generalized Anxiety Disorder-7 (GAD-7) was the assessment tool used to determine current anxiety symptoms. Multivariate Logistic regressions at 95% CI and p< 0.05 were used to identify factors associated with the outcome variable.

Results: This study enrolled a total of 326 respondents, and the overall prevalence of GAD was 40.2%. Variables associated with General anxiety disorder were being female, family size 3+, nurses, working in out-patient and emergency service, and ≤ 3years working experience at 95% confidence interval, p< 0.05.

Conclusions: This study found that more than one-third of the respondents had a general anxiety disorder in response to the pandemic, and identified groups of the participants were female, nurses, family size 3 +, and ≤ three years of working experience. So there should be immediate psychological intervention and training for an identified group of peoples to promote the mental health status of health professionals for better and quality health service.

 

Original Research Article

TRANSFER LEARNING METHOD FOR SLEEP STAGES CLASSIFICATION USING DIFFERENT DOMAIN

MOHAMMAD MAHDI MORADI, MOHAMMAD H. FATEHI, HASSAN MASOUMI, MEHDI TAGHIZADEH

Asian Journal of Advances in Medical Science, Volume 2, Issue 3, Page 21-25

Sleep stages classification using the signal analysis includes electroencephalogram (EEG), Electrooculography (EOG), Electromyography (EMG), Photoplethysmogram (PPG), and electrocardiogram (ECG). In this study, the proposed method using transfer learning to sleep stages classification. First, we have used the PPG and ECG signals, because they are less complex. This signal has the least complexity, and in this article we used this signal for transitional learning. n this study, we extracted 52 features from two signals and prepared for the classification stage. This method includes two steps, (a) Train data PPG and Test data ECG, (b) Train data ECG and Test data PPG. Results proved that our method has acceptable reliability for classification. The accuracy of 95.25% and 94.63% has been reached.

Original Research Article

PHARMACOLOGICAL AND ANTI CANCER ACTIVITY OF Ipomoea sepiaria METHANOLIC EXTRACT AGAINST PC-3 CELL LINE

S. AZHAGU MADHAVAN, P. VINOTHA, V. UMA

Asian Journal of Advances in Medical Science, Volume 2, Issue 3, Page 26-32

A few conventional restorative plants contain in explored concerning their enemy of corpulence likely wellsprings of is Ipomoea sepiaria Koenig ex. Roxb. The medicine is supposed in tales game plan of prescription for various accommodating properties like, love elixir and arsenic hurting, tonic, re-establishing, diuretic, laxative, uterotonic and sterility in women and leaves is shown particularly in diabetes. Phytochemical screening of different concentrates of Ipomoea sepiaria exposed the presence and non-attendance of various phytochemicals are available in ethanol remove, further examinations were done with leaves of Ipomoea sepiaria ethanol separate. PC3 (PC-3) is a human prostate malignancy cell lines that are profoundly utilized in examining the biochemical changes prostatic disease cells. Explores on PC-3 human prostate malignancy cell lines control are required in the current many years. The anticancer action of fluid concentrate of Ipomoea sepiaria was researched by 3-(4,5-dimethylthiazol-2-yl)- 2, 5-diphenyltetrazolium (MTT) measure utilizing PC-3 cell line. The current experimentation was indicated that watery concentrate of Ipomoea sepiaria, when exposed to various focuses on PC-3 cells demonstrated IC50 cell hindrance at about 5μM for 48 hours and about 2 μM for 72 hours. The information made by this particular examination gives relevant pharmacognostic  and phytochemical data needed for proper distinctive confirmation and check of leaves of this particular  species.

 

Review Article

EPIDEMIOLOGY OF CHRONIC LIVER DISEASE IN NIGERIA: A REVIEW

AGADA, SAMUEL ALI, ODAMA, RICHARD IKANI, KENECHUKWU, CHIBUIKE ONYEKWELU, OKANG, SUNDAY OBI, EZEH, CHARLES OGBONNA

Asian Journal of Advances in Medical Science, Volume 2, Issue 3, Page 1-6

Chronic liver disease is one of the major health issues which occur throughout the world irrespective of age, sex, region or race. Liver diseases have being ranked the fifth most common cause of death and the second leading cause of mortality amongst all digestive diseases with approximately 2 million deaths per year worldwide. Aimed at determining the relative prevalence of chronic liver diseases in Nigeria, this shows that up to 46% of global diseases and 59% of the mortality is due to chronic liver diseases and almost 35 million people in the world die of chronic diseases with liver disease rate steadily increasing over the years. In Nigeria, (35 million) 2-20% of the population, are infected with hepatitis B and C virus with a prevalence rate of 4.3%-23.3% and 0.5-15% been reported respectively from different part of the country depending on the geographical location. A prevalence rate of 4.3% was reported from Port Harcourt, 5.7% from Ilorin, 11.6% from Maiduguri, and 8.3% from Zaria, 6.78% from Ado-Ekiti among pregnant women, 13.50% from Lagos, 11.50% from Abuja Urban among HIV Patients with a seroprevalence of 23.3% been reported among patients attending all clinics in Kano.

Systematic Reviews

CURRENT ADVANCEMENTS ON THE EFFICACY OF CONVALESCENT PLASMA AS A POTENTIAL PROMISING TREATMENT FOR COVID-19

S. D. NGULUBE PETER, DIGVIJAY PANDEY

Asian Journal of Advances in Medical Science, Volume 2, Issue 3, Page 7-12

Purpose: No sooner had COVID-19 hit the world in December, 2019 in Wuhan, China, than the emergence of tremendous developments on the therapeutic interventions for the pandemic. No therapy has been proved successful up to date regardless potentiality of several intervention that are still in clinical trials. However Convalescent plasma demonstrated some sort of interest to be potential for the treatment of COVID-19 as we are still waiting for a specific therapy or vaccine. This review discusses current developments that supported the efficacy of convalescent plasma to attract its potentiality for treating COVID-19.

Methods: A systematic search with a search term “efficacy of convalescent plasma on COVID-19” was done on PubMed, Google Scholar, Science direct, Research Gate and clinicaltrials.gov database. A search was conducted based on all the literature discussing the current advancements on the use of convalescent plasma as a potential treatment for coronavirus, however only studies that discussed its efficacy were retrieved in this review.

Results: We retrieved a total of 24 articles discussing the current developments on the use of convalescent plasma as a potential treatment for COVID-19. 70% of the articles discuss its success, 20% of the articles evaluate current ongoing clinical trials for convalescent plasma while the remaining 10% present concerns on the inappropriate administration of convalescent plasma as a COVID-19 therapy.

Conclusion: Several discussed studies demonstrated much attention on the use of convalescent plasma as a potential promising therapy for COVID-19, although this has not been proven. However, other studies expressed concerns over the inappropriate administration of the therapy where COVID-19 patients ended up developing a pro- thrombotic disease.

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