ANTI-DIABETIC POTENTIAL OF Spatoglossum asperum (BROWN SEAWEED); INSILICO MODEL
ANDREWS SEKAR
PG & Research Department of Zoology, A.V.V.M. Sri Pushpam College (An Autonomous Institution Affiliated to Bharathidasan University), Poondi, Thanjavur 613503, Tamil Nadu, India.
GURUSAMY CHELLADURAI
Department of Zoology, G. Venkataswamy Naidu College (Autonomous), Kovilpatti-628502, Tamil Nadu, India.
SUBRAMANIYAN VAITHILINGAM
PG and Research Department of Biotechnology, JJ College of Arts and Science College (Autonomous), Pudukottai, Tamil Nadu-622422, India.
ARJUN PANDIAN
Division of Research & Innovation, Department of Biotechnology, Saveetha School of Engineering (SSE), Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai – 602105, Tamil Nadu, India.
AZHAGU MADHAVAN SIVALINGAM
Department of Community Medicine, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai – 602105, Tamil Nadu, India.
GANESAN SIVAMANI *
PG & Research Department of Zoology, A.V.V.M. Sri Pushpam College (An Autonomous Institution Affiliated to Bharathidasan University), Poondi, Thanjavur 613503, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
This study used GC-MS analysis and computational biology to examine the diabetic effect of bioactive substances obtained from brown seaweed. Using AutoDock/Vina in Pymol 4.2, the molecular docking of Spatoglossum asperum on the human PPAR- protein was determined and compared to that of the well-known PPAR- agonist Gilbenclamide. The analysis the active components of seaweed extracts is the main focus of the current investigation. 12 substances were discovered using GC-MS analysis and evaluated using AutoDock/Vina against PPAR. Docking tests showed that the existing phytochemical 9-Octadecenoic Acid (Z)-, Octadecyl Ester, obtained from seaweed, has the highest fitness score of -398.9 kcal/mol and may therefore be a potent anti-diabetic drug. This study could result in the creation of brand-new marine nutraceuticals that use brown seaweed to treat a number of diseases.
Keywords: Antidiabetic drug, auto dock, brown seaweeds, computational biology, gilbenclamide