UTTAR PRADESH JOURNAL OF ZOOLOGY

The present work was aimed to assess the effect of vitamin E (vit. E) and magnesium malate against aluminium chloride (AlCl₃) toxicity on antioxidant enzymes xanthine oxidase (XOD), super oxide dismutase (SOD) and catalase (CAT)activities in liver tissues of albino rats. Rats were divided in to five groups, group I received normal saline, group II administered orally with AlCl₃ (7.5 mg kg bw), group III received magnesium malate (5.0 mg/ kg bw), group IV received with AlCl₃ and vitamin E(10 mg kg bw) and group V  with AlCl₃, Magnesium malate and vit E. The antioxidant enzyme XOD activity levels were increased in AlCl₃ treated animals and gradual decrease was observed in magnesium malate and vit. E treated animals, SOD activity was decreased in AlCl3 treated animals where increase was observed in magnesium malate and vitamin E treated animals, the catalase (CAT) activity was decreased in AlCl3 treated animals where increase was observed in magnesium malate and vitamin E (vit-E) treated animals. The results indicated that the toxic effect of AlCl₃ could be mediated through modifying antioxidant enzyme activity in rat liver which may lead to impaired function. The combined treatment with magnesium malate and vit E was effective in the restoring the studied parameters near to the normal.