Effect of Geinstein on Regulation of Estrous Cycle in Albino Rats, Isolated from Flemingia vestita, an Ethnomedicinally Important Plant of Meghalaya, India
Afsana Khatun
Department of Zoology, School of Biological Sciences, University of Science and Technology Meghalaya, RiBhoi, Meghalaya, India.
Syed Rizaul Karim Ahmed
Department of Zoology, School of Biological Sciences, University of Science and Technology Meghalaya, RiBhoi, Meghalaya, India.
Sudipta Nag
Department of Zoology, School of Biological Sciences, University of Science and Technology Meghalaya, RiBhoi, Meghalaya, India.
Kangkan Jyoti Sarma
*
Department of Zoology, School of Biological Sciences, University of Science and Technology Meghalaya, RiBhoi, Meghalaya, India.
*Author to whom correspondence should be addressed.
Abstract
Flemingia vestita is a flowering plant belonging to the family of Fabaceae which is usually found in the Indian region including Khasi and Jaintia Hills of Meghalaya, India. It is cultivated for therapeutic use for its anti-microbial, anti-fungal, anti-helmintic, anticancer, anti-rheumatic, anti-inflammatory, antioxidant, and anti-histamine activities. The present study is to ascertain the phytochemical analysis of the root-tuber extract and modulating the effect of the Estrous Cycle in albino mice using Geinstein. The phytoestrogens present in the extract are iso-flavones and genistein which have a wide spectrum of biological activities including estrogenic effect. The number of leucocytes during the Meta-estrous at 0.1 ml/10 gm dose/body weight was maximum at ethanol extract while at 0.3 ml/10 gm dose/body weight was similar and maximum in both ethanol and methanol extract. Comparative cell number of interstitial connective tissues was maximum in ethanol followed by methanol and acetone extract. The present study concluded that the extract has a potential to modulate the estrogenic cycle in albino rats.
Keywords: Flemingia vestita, genistein, ethnomedicinal, estrous cycle, Meghalaya